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. Author manuscript; available in PMC: 2013 Jul 30.
Published in final edited form as: Bioorg Med Chem. 2012 Mar 12;20(9):3009–3015. doi: 10.1016/j.bmc.2012.03.004

Table 1.

Anticancer activity of tricyclic targets

Compound IC50a(µM)
L1210 CEM HeLa HEL
5 144 ± 15 166 ± 54 81 ± 10 22
6 53 ± 4 82 ± 39 57 ± 40 12
a

50% inhibitory concentration or compound concentration required to inhibit cell proliferation by 50%.