Table 2.
Antiviral activity of targets 5 and 6 in cell culture
| Virus | EC50a (µM) | ||
|---|---|---|---|
| 5 | 6 | Ribavirin | |
| HEL cells | |||
| HCMV (AD-169 & Davis) | >100 | >4 | — |
| VZV (OKA & 07/1) | 71.3–100 | 8.9 | — |
| HSV-1 (KOS) | >100 | >20 | >250 |
| HSV-1 TK− | >100 | >20 | >250 |
| HSV-2 (G) | >100 | >20 | >250 |
| VV | >100 | >20 | >250 |
| VSV | >100 | >20 | 146 |
| HeLa cells | |||
| VSV | 100 | >100 | 29 |
| Coxsackie virus B4 | >100 | >100 | 146 |
| RSV | >100 | >100 | 10 |
| CEM cells | |||
| HIV-1(IIIB) HIV-2(ROD) | ≥250 | >10 | >50 |
| Vero cells | |||
| Parainfluenza-3 virus | >100 | >100 | 85 |
| Reovirus-1 | >100 | 100 | >250 |
| Sindbis virus | >100 | 100 | >250 |
| Coxsackie virus B4 | >100 | >100 | >250 |
| Punta Toro virus | >100 | 100 | 126 |
| MDCK cells | |||
| Influenza virus (AH3N2) | >0.16 | >4 | 5.1–9.0 |
| Influenza virus A (H1N1) | >0.16 | >4 | 2.3–3.4 |
| Influenza virus B | >0.16 | >4 | 4.5–9 |
| Cell line MCCb (µM) | |||
| HEL | >100 | ≥20 | >250 |
| HeLa | 100 | >100 | >250 |
| Vero | 100 | >100 | >250 |
| MDCK | 0.8 | 20 | 20 |
a
50% Effective concentration, or compound concentration required to inhibit virus-induced cytopathicity by 50%.
b
Minimal cytotoxic concentration, or compound concentration required to cause a microscopically visible alteration of cell morphology.