Table 1.

Effect of menthol on cold-evoked responses during the static period of cooling in control and dry eye animals

		Menthol Concentration
	Vehicle	10 μM	50 μM	100 μM	500 μM	1.0 mM
Control	0.67 ± 0.53	0.39 ± 1.63	−0.22 ± 1.00	0.21 ± 0.88		−2.91 ± 2.23
Dry eye	0.55 ± 0.51	5.20 ± 2.35	0.57 ± 1.77	−2.66 ± 1.01	−5.09 ± 1.40*

Values represent average discharge (spikes/s) evoked during the final 30 s of the cooling stimulus, calculated by taking the difference in cold-evoked discharge during a baseline stimulation trial from cold discharge evoked after either vehicle or menthol application (see materials and methods for details).

^*P < 0.05 vs. vehicle treatment, Kruskal- Wallis 1-way ANOVA on ranks and Dunn's methods.