Table 3.
Imax and pH50 in response to protons in bladder sensory neurons
| Fast | Intermediate | Sustained | |
|---|---|---|---|
| Sal LS | |||
| Imax, pA/pF | 68.6 ± 12.7 (19) | 63.3 ± 10.0 (19) | 134.0 ± 12.0 (10) |
| pH50 | 5.6 ± 0.1 (19) | 5.4 ± 0.1 (19) | 4.5 ± 0.1 (10) |
| Sal TL | |||
| Imax, pA/pF | 62.3 ± 12.8 (11) | 46.9 ± 11 (11) | 93.8 ± 14 (10) |
| pH50 | 5.5 ± 0.2 (11) | 5.9 ± 0.3 (11) | 4.7 ± 0.1 (10) |
| CYP LS | |||
| Imax, pA/pF | 29.5 ± 8.4* (20) | 24.7 ± 7.3* (20) | 81.6 ± 16* (14) |
| pH50 | 5.7 ± 0.1 (20) | 5.5 ± 0.1 (20) | 4.7 ± 0.1 (14) |
| CYP TL | |||
| Imax, pA/pF | 38.9 ± 5.3* (18) | 22.3 ± 2.4* (18) | 57.1 ± 11.5* (8) |
| pH50 | 5.3 ± 0.1 (18) | 5.5 ± 0.1 (18) | 4.6 ± 0.1 (8) |
Values are means ± SE of peak current (Imax) and logarithm of EC50 for protons (pH50) for various proton-triggered components in LS and TL bladder sensory neurons from saline (control)- and CYP-treated rats (no of neurons in parentheses).
*
P < 0.05 vs. saline-treated counterparts.