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. 2013 Apr 26;305(1):H1–H8. doi: 10.1152/ajpheart.00080.2013

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Fig. 1. — A and B: chronic isoproterenol (Iso) exacerbated cardiomyopathy in transgenic overexpression of adenylyl cyclase 5 in cardiomyocytes of the heart (AC5-Tg) compared with wild-type (WT), and the cardiomyopathy was rescued by mating the AC5-Tg mice with MnSOD-Tg (AC5-Tg × MnSOD-Tg) mice (41). C and D: downregulation of MnSOD eliminated the protective effects of AC5-knockout (KO) with chronic Iso. LV, left ventricular; EF, ejection fraction. *P < 0.05 (41). Figures used are modified with permission from Lai et al. (41).