Fig. 5.

Quantitative RT-PCR of 6-mo-old wild-type and Ryr2^D/D mice. RT-PCR was performed with total RNA from left ventricles of 6-mo-old mice. RNA levels were normalized to those of wild type for each gene. α-MHC, α-myosin heavy chain; β-MHC, β-myosin heavy chain; ANP, atrial natriuretic peptide; BNP, brain natriuretic peptide; Ca_v1.2, L-type Ca²⁺ channel; RyR2, cardiac ryanodine receptor; IP₃R, inositol trisphosphate receptor; CSQ2, calsequestrin; SERCA2a, sarco(endo)plasmic reticulum Ca²⁺-ATPase 2a; NCX1, sodium-calcium exchanger 1. Data are means ± SE of 9–16 samples. *P < 0.05 compared with Ryr2^+/+.