Table 1.

Echocardiography in 6-mo-old wild-type and mutant mice

Parameters	Ryr2+/+ (n = 13)	Ryr2+/D (n = 15)	Ryr2D/D (n = 11)
HR, beats/min	542 ± 30	449 ± 30	491 ± 23
LVEDD, mm	2.82 ± 0.12*	3.34 ± 0.08	3.00 ± 0.12
LVESD, mm	1.40 ± 0.10*	1.90 ± 0.09	1.54 ± 0.12
FS, %	50.6 ± 2.6	43.2 ± 1.8	49.3 ± 2.4
IVSD, mm	1.23 ± 0.07	1.06 ± 0.06	1.22 ± 0.07
IVSS, mm	1.77 ± 0.10	1.54 ± 0.06	1.83 ± 0.10
LVPWD, mm	1.10 ± 0.07	0.97 ± 0.04	1.34 ± 0.11*
LVPWS, mm	1.69 ± 0.09	1.47 ± 0.04	1.79 ± 0.13*

Data are means ± SE for n mice.

HR, heart rate; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension; FS, fractional shortening [LVEDD − LVESD)/LVEDD]; IVSD, interventricular septum diastolic thickness; IVSS, interventricular septum systolic thickness; LVPWD, left ventricular posterior wall diastolic thickness; LVPWS, left ventricular posterior wall systolic thickness.

^*P < 0.05 compared with heterozygous mice.