Table 3.

Echocardiography of Ryr2^+/+ and Ryr2^D/D mice after TAC

	Sham		TAC
Parameters	Ryr2+/+ (n = 8)	Ryr2D/D (n = 8)	Ryr2+/+ (n = 6)	Ryr2D/D (n = 8)
HW/BW, %	0.55 ± 0.01	0.56 ± 0.01	0.63 ± 0.03	0.79 ± 0.07*†
HR, beats/min	583 ± 33	573 ± 27	650 ± 10	587 ± 19
LVEDD, mm	2.67 ± 0.15	2.18 ± 0.09*	2.59 ± 0.10	2.42 ± 0.08
LVESD, mm	1.25 ± 0.17	0.67 ± 0.07*	1.12 ± 0.09	0.96 ± 0.15
FS, %	55.0 ± 5.1	69.4 ± 2.4	57.1 ± 2.1	60.4 ± 5.6
IVSD, mm	1.12 ± 0.13	1.37 ± 0.06	1.36 ± 0.08	1.59 ± 0.14*
IVSS, mm	1.75 ± 0.18	2.10 ± 0.07	2.04 ± 0.09	2.33 ± 0.11*
LVPWD, mm	1.07 ± 0.14	1.32 ± 0.06	1.39 ± 0.11	1.67 ± 0.13*
LVPWS, mm	1.62 ± 0.21	1.89 ± 0.09	1.88 ± 0.13	2.22 ± 0.13

Data are means ± SE for n mice.

HW/BW, heart weight-to-body weight ratio; Sham, sham operated; TAC, transverse aortic constriction.

^*P < 0.05 compared with Sham Ryr2^+/+;

^†P < 0.05 compared with Sham Ryr2^D/D.