Fig. 2.

Contractile responses are enhanced in mesenteric arteries isolated from CPI-17-Tg mice. Second-order branches of mesenteric arteries were isolated from 12- to 14-wk-old male CPI-17-Tg and WT control mice, cut into helical strips, and denuded of endothelia. Isometric contractions in response to cumulative doses of phenylephrine (PE, A, D, and G), U-46619 (B, E, and H), serotonin (5-HT, C, F, and I), 100 nM ANG II (J), or 143 mM high-potassium solution (K) were determined. In addition, some of the strips were permeabilized by Staphylococcus aureus α-toxin, and cumulative concentrations of calcium were added to obtain the pCa-tension curve (L). *P < 0.05 and **P < 0.01.