Table 3.
LV hemodynamic function at baseline and following β-adrenergic stimulation
| WT |
MyBP-C+/− |
|||
|---|---|---|---|---|
| BL | Dob | BL | Dob | |
| HR, beats/min | 410 ± 16 | 441 ± 16 | 404 ± 5 | 442 ± 12 |
| ESP, mmHg | 94.4 ± 4.1 | 80.2 ± 11.0 | 93.9 ± 5.2 | 79.5 ± 8.7 |
| EDP, mmHg | 5.01 ± 0.53 | 6.04 ± 1.83 | 7.58 ± 1.08* | 4.75 ± 0.81* |
| EF, % | 75.0 ± 4.9 | 90.2 ± 3.2 | 65.0 ± 6.9 | 91.0 ± 4.1 |
| dP/dtmax, mmHg/s | 7964 ± 273 | 11072 ± 961 | 6314 ± 643* | 9899 ± 1067 |
| τ, ms | 9.50 ± 0.87 | 8.15 ± 0.56 | 10.6 ± 0.7 | 9.70 ± 0.99 |
Data are means ± SE of responses determined at baseline (BL) or 5 min after dobutamine (Dob) injection. HR, heart rate; ESP, end-systolic pressure; EDP, end-diastolic pressure; EF, ejection fraction; dP/dtmax, peak rate of pressure rise; τ, relaxation time constant. Data are averages from 9 mice/group.
*
P < 0.05 compared with WT.