Figure 5.

Figure 5A. Measured rates of myocardial FDG uptake in vivo.. Ki (ml/g/min) for the mice in sham (n=5), TAC, vehicle (n=5) and TAC, propranolol (n=6) mice are shown in this figure. The figure shows increased myocardial FDG uptake at day 1 post TAC surgery by 580% indicating an adaptive response to stress. Ki increased further on day 7 in the TAC mice, while the TAC mice treated with propranolol exhibited attenuated rate of myocardial FDG uptake over the 7 days period. The metabolic changes in the TAC mice treated with propranolol were comparable to the shams. All values are mean ± SEM. *, #p<0.05 vs BSL, TAC treated with propranolol and sham groups.

5B. Measured LVEF from dynamic gated PET images in vivo. The plot indicates an insignificant drop in function in the TAC mice on day 1. On day 7 the function dropped by 24% in the TAC mice while there is an insignificant drop in function in the TAC mice treated with propranolol. The shams indicate no significant change in function over the 7 days period. All values are mean ± SEM. *p<0.05 vs BSL, TAC treated with propranolol and sham groups.