Table 6.
List of hydrogen bond forming and hydrophobic interacting residues between TLR2-TIR and MyD88-TIR domains.
| Hydrogen bonds | Hydrophobic interactions | |||
|---|---|---|---|---|
| Donor | Acceptor | Length (Å) | Donor | Acceptor |
| Trp689-NE1 | Leu84-O | 1.97 | Ala73 | Gln654 |
| Ser715-O | Ser50-N | 2.34 | Gln77 | His655 |
| Ser715-O | Ile48-O | 2.84 | Tyr8 | Asp656 |
| Ser715-OG | Asp36-OD2 | 2.78 | Ser71 | His680 |
| Asp723-OD2 | Lys55-NZ | 2.70 | Asp72 | Lys681 |
| Thr714-N | Asp36-OD2 | 2.62 | Cys9 | Arg682 |
| Thr714-O | Asp36-O | 2.72 | Phe76 | Phe684 |
| Ser83-OG | Gly687-N | 2.94 | Lys79 | Pro686 |
| Gln654-NE2 | Asp38-OD2 | 2.72 | Leu82 | Gly687 |
| Ser11-SG | Asp656-OD1 | 3.15 | Ser83 | Trp689 |
| Cys9-NZ | Asp656-OD1 | 2.70 | Phe80 | Ile690 |
| Asp72-N | Asp656-OD2 | 2.56 | Leu84 | Glu710 |
| Cys9-NZ | His655-O | 2.61 | Cys85 | His711 |
| Cys9-NZ | His655-ND1 | 2.78 | Pro86 | Val713 |
| Pro686-O | Ser50-OG | 2.14 | Asp36 | Thr714 |
| Arg688-NH2 | Glu51-OE2 | 2.75 | Ala73 | Gln654 |
| Asp692-OD1 | Lys10-NZ | 2.20 | Gln77 | His655 |
| Lys681-NZ | Asp72-OD2 | 2.73 | Tyr8 | Asp656 |
| His655-NE2 | Asp75-OD2 | 1.91 | Ser71 | His680 |