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. 2013 Jul 15;2013:812029. doi: 10.1155/2013/812029

Table 3.

Mechanisms leading to autoantibody production in EBA.

Mechanism Demonstrated by Reference
Genes within MHC locus (i) HLA haplotype in EBA patients
(ii) MHC association in experimental EBA
[8, 68, 80]

Genes outside MHC locus (i) Overrepresentation of black-skinned patients in EBA
(ii) Identification of quantitative trait loci (QTL) in experimental EBA
[8, 77]

CD4 T cells (i) T-cell-deficient nude mice are resistant to induction of immunization-induced EBA
(ii) Time-restricted depletion identifies CD4 T cells to be required for induction of immunization-induced EBA
[66, 83]

HSP90 Blockade of HSP90 prevents induction of and improves already established immunization-induced EBA [84]