Table 3.
Mechanism | Demonstrated by | Reference |
---|---|---|
Genes within MHC locus | (i) HLA haplotype in EBA patients (ii) MHC association in experimental EBA |
[8, 68, 80] |
| ||
Genes outside MHC locus | (i) Overrepresentation of black-skinned patients in EBA (ii) Identification of quantitative trait loci (QTL) in experimental EBA |
[8, 77] |
| ||
CD4 T cells | (i) T-cell-deficient nude mice are resistant to induction of immunization-induced EBA (ii) Time-restricted depletion identifies CD4 T cells to be required for induction of immunization-induced EBA |
[66, 83] |
| ||
HSP90 | Blockade of HSP90 prevents induction of and improves already established immunization-induced EBA | [84] |