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. 2013 Jun 28;453(Pt 2):155–166. doi: 10.1042/BJ20130316

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© 2013 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A) The structure of PfuCas10b^dHD (PDB code 3UNG) in complex with ADP (red sticks). The ferredoxin-like folds are coloured as for RAMPs and the additional adenylate cyclase elements are shown in orange. D4 is shown in yellow to highlight its homology with the small subunits. The three metal ions are shown as grey spheres. Inset: schematic diagram showing the relative positions of the four domains (D1–D4) with the cyclase-like domains in blue and the small subunit-like domain in yellow. (B) The structure of the Cas10b^dHD–Cmr3 complex (PDB code 4H4K) with Cmr3 shown in navy blue and Cas10b^dHD as in (A). The putative crRNA-binding cleft is indicated with a solid black line. (C) The structure of Cse1 from T. thermophilus (PDB code 4AN8) with the disordered loop L1 indicated.