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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Nat Genet. 2013 Apr 14;45(6):602–612. doi: 10.1038/ng.2611

Figure 1. Clinicopathological characteristics and genetic alterations in tumors from series 1 examined by WGS or mRNA-seq.

Figure 1

a Summary of clinicopathological characteristics (Tumor site, Pathology, Age at surgery, Sex) and key genetic alterations identified in 56 LGGs/LGGNTs by WGS (n=38) or mRNA-seq (n=44). Very few SVs or SNVs are found across the WGS tumor series. Numbers of aberrations for tumor samples highlighted in beige were based on analysis of mRNA-seq alone. Numbers in colored cells refer to gene fusions listed in box at right below table. b Selected CIRCOS plots summarizing aspects of WGS data, including a solitary KIAA1549-BRAF fusion (SJLGG001), MYB rearrangement (SJLGG005), FGFR1 TKD-duplication (SJLGG006), and NF1 mutation (SJLGG022). The genomic profiles of two oligodendroglial tumors, SJLGG006 and SJLGG034, illustrate some key differences between this type of tumor in children and in adults, the latter demonstrating IDH1 and CIC mutations alongside 1p/19q co-deletion. SJLGG039 exemplifies five LGGs with complex rearrangements.