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. 2013 Aug;142(2):113–126. doi: 10.1085/jgp.201310996

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© 2013 Mesirca et al.

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Figure 1. — Distribution and localization of anti-Girk immunoreactivity in isolated mouse atrio-sinus preparations. (A) Representative images of n = 3 isolated SAN right atrium (RA) preparations (endocardial side) double stained with HCN4 and Girk4 antibodies. CT, crista terminalis; IVC and SVC, inferior and superior vena cava, respectively. (B) Close-up views of pacemaker cells within the SAN stained with HCN4, Girk4, or Girk1 antibodies. Individual HCN4-positive cells within the SAN region of WT hearts showed strong membrane-associated Girk4 and Girk1 immunoreactivity (top). Girk4^−/− SAN cells displayed HCN4-positive and Girk4-negative staining and no membrane-bound Girk1 (bottom). Bars, 10 µm.