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. 2013 Aug;142(2):113–126. doi: 10.1085/jgp.201310996

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© 2013 Mesirca et al.

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Figure 2. — Inactivation of Girk4 channels ablates I_KACh in mouse SAN cells. (A) Sample traces of I_KACh current in WT and Girk4^−/− SAN cells. I_KACh was activated by ACh in WT and Girk4^−/− SAN cells. Arrows indicate the period of time for which ACh was added. (B) I_KACh density at different ACh concentrations in SAN cells from WT (0.003–10 µM; n = 4–16; closed circles) and Girk4^−/− (0.003–10 µM; n = 3–13; open circles) mice. Error bars represent SEM. Statistical symbols: *, P < 0.05; and **, P < 0.01.