Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Aug;142(2):113–126. doi: 10.1085/jgp.201310996

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 Mesirca et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 3. — Loss of I_KACh in Girk4^−/− mice did not affect functional expression of I_f and I_Ca,L. (A, left) Isochronal current to voltage curves for I_f in SAN cells from WT (n = 8; closed circles) and Girk4^−/− (n = 10; open circles) mice. (right) Representative voltage-clamp recordings of I_f in isolated WT and Girk4^−/− SAN cells. Applying hyperpolarizing voltage steps from a holding potential of −30 mV evoked I_f current. (B, left) Isochronal current to voltage curves of I_Ca,L in SAN cells from WT (n = 12; closed circles) and Girk4^−/− (n = 9; open circles). (right) Sample traces of I_Ca,L in SAN cells from WT and Girk4^−/− mice. Recordings were obtained by applying depolarizing voltage steps from a holding potential of −55 mV. Voltage-clamp protocols are shown below the traces, and the dashed lines indicate the zero voltage. Error bars represent SEM.