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. 2013 Aug;142(2):113–126. doi: 10.1085/jgp.201310996

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© 2013 Mesirca et al.

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Figure 5. — Negative chronotropic response to ACh of isolated WT and Girk4^−/− hearts. (A and B) Dose–response relations expressed as absolute values (bpm; A) or percentage of heart rate (HR) slowing (B) by ACh in n = 7 WT (closed bars and circles) and n = 8 Girk4^−/− Langendorff-perfused hearts (open bars and circles). (C) Sample traces of ECGs recorded from Langendorff-perfused hearts at baseline and after 0.3 µM ACh in WT and Girk4^−/−. Note that reduction in heart rate was more pronounced in WT than in Girk4^−/− hearts. Error bars represent SEM. Statistical symbols: *, P < 0.05.