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. 2013 Jul 29;210(8):1493–1500. doi: 10.1084/jem.20130212

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© 2013 Li et al.

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Figure 5. — sH1N1 preexposure alters the specificity of pH1N1 antibody responses in ferrets. (A–D) HAI assays were completed using viruses possessing either wild-type A/California/07/2009 HA, or A/California/07/2009 HA with G158E or K133N mutations. Sera were isolated from ferrets sequentially infected with a sH1N1 strain, and then the A/California/07/2009 pH1N1 strain. Infections were completed 84 d apart and sera were isolated 14 d after infection with the pH1N1 virus. Fold change for each mutant virus (WT HAI titer/mutant HAI titer) is shown here. Each triangle represents an individual sera sample, and the mean is indicated with a line. Differences in K133 specificity were statistically significant between the different preexposed groups (Fisher’s exact test; *, P = 0.003 comparing HAI titers of sera isolated from A/Texas/36/1991 preexposed animals to HAI titers of sera isolated from animals preexposed with other sH1N1 viruses). Data are representative of two independent experiments.