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. 2013 Jul 29;210(8):1545–1557. doi: 10.1084/jem.20122516

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© 2013 Mansour et al.

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Figure 4. — Inhibition of miR-223 impairs growth and induces apoptosis in TAL1-positive T-ALL cell lines. Four cell lines were transduced with a control miRZip shRNA or an shRNA targeting miR-223 (miRZip-223) and growth kinetics were analyzed. (A) Jurkat cells, harboring a heterozygous FBXW7 R505C mutation (B) CCRF-CEM, harboring a heterozygous FBXW7 R465C mutation (C) MOLT-16, wild-type for FBXW7 and (D) Be-13, which have biallelic deletion of the FBXW7 locus. (E) Annexin V expression was determined by flow cytometry in T-ALL cells 72 h after transduction with control miRZip versus miRZip-223. (F) Jurkat cells were transduced with a retrovirus to overexpress miR-223 and the growth kinetics analyzed after transduction with miRZip-control or miRZip-223 shRNA constructs. All data points represent mean ± SEM for triplicate experiments. P values are for *, P < 0.05; **, P < 0.01; and ***, P < 0.001 by two tailed t test for each time point.