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. 2013 Jul 29;210(8):1545–1557. doi: 10.1084/jem.20122516

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© 2013 Mansour et al.

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Figure 7. — TAL1 stabilizes a host of oncogenic substrates through the repression of FBXW7. Western blots for TAL1, FBXW7, and its substrates MYC, MYB, intracellular NOTCH1 (ICN-1), MTOR, MCL-1 (L, long isoform; S, short isoform), and CYCLIN E 48 h after the addition of doxycycline in doxycycline-inducible TAL1-knockdown Jurkat S1C1 cells. Representative blots from three independent experiments are shown.