Figure 4.

Stereo representation of electron density of the panthetheine cofactor and inhibitor. Unbiased electron density calculated with coefficients of the form F _o − F _c generated after molecular replacement and prior to inclusion of any ligands or water molecules in the structure. Density is contoured at 2.5σ and is displayed with a carve radius of 4 Å around the ligands. The discontinuity in the density near the covalent attachment was not apparent in the final 2F _o − F _c map; however, it may represent some fractional incomplete reaction of the pantetheine and inhibitor.