Table 2.
Estimates of parameters for hematology dynamics
| Parameter (units) | Definition | Estimate WKY/GK | CV% |
|---|---|---|---|
| ks (week−1) | Growth constant in Gompertz equation | 0.134 | 13.0 |
| α (week−1) | Retarding constant in Gompertz equation | 0.287 | 15.7 |
| kd (week−1) | First-order rate constant for change in ksyn(t) | 0.0210/0.0878 | 95.0/134 |
| ksyn_min (pg/cell/week) | Minimal value of ksyn(t) | 6.75/6.61 | 43.7/43.7 |
| ksyn0 (pg/cell/week) | Initial value of ksyn(t) | 8.48/7.97 | Fixeda |
| kout (week−1) | Loss rate constant of MCH | 0.571 | 69.8 |
| kout_HA (week−1) | Elimination rate constant of HbA1c | 1.123 | 35.9 |
| RBC0 (× 106 cells/µl) | Initial value of RBC count | 4.55/5.39 | Fixedb |
| MCH0 (pg/cell) | Initial value of MCH | 23.0/21.6 | Fixedb |
| HbA1c0 (%) | Initial value of HbA1c | 4.18/4.62 | Fixedb |
a
Secondary parameter
b
Parameter fixed as mean of experimental data