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. 2013 Feb 13;33(7):2916–2926. doi: 10.1523/JNEUROSCI.3607-12.2013

Figure 3.

Figure 3.

Optical stimulation of SACs generates a GABAA receptor-mediated monosynaptic IPSP, followed by rebound excitation in ETCs. A–C, Top, Twenty current-clamp traces showing responses of the same ETC to optical stimulation of distant glomeruli in normal ACSF (A), ACSF containing 10 μm NBQX and 50 μm APV (B), and ACSF containing NBQX, APV, and 10 μm GBZ (C). Middle, Raster plots showing spike distribution across 20 individual traces in corresponding conditions. Blue vertical lines indicate the blue laser light exposure. Bottom, Spike histogram averaged from eight ETCs (20 traces/cell) showing fast inhibition, followed by rebound excitation in response to optical stimulation of distant glomeruli in corresponding conditions shown in the top. D, Close-up of IPSPs evoked by optical stimulation of distant glomeruli within the purple rectangles shown in the corresponding top panels. Thick traces represent the average from 20 traces (gray). E, Population data showing the IPSP onset and peak latencies (n = 8 cells). F, G, Population data from eight cells showing the effects of NBQX + APV, or NBQX + APV plus GBZ on IPSP amplitude (F) and rebound spiking (G). ***p < 0.001 (n = 8 cells, one-way repeated-measure ANOVA with Bonferroni's test).