FIG. 6.

Reduced mir-21 expression increases apoptotic cell death following spinal cord injury (SCI). Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining was used to analyze neuronal apoptosis (arrow) after SCI. Representative microscopy images of spinal cord sections taken 1 (A) and 3 days (B) post-injury in negative control and antagomir-21 groups, respectively. The antagomir-21 group at 3 days after SCI (n=4) had a higher proportion of TUNEL-positive cells than did the negative control group (n=4) (C). Bars represent means±SEM. *p<0.05. Scale bar=50 μm.