Table 1.

Radiochemical yields of [¹⁸F]fluoroarenes from the microfluidic NCA radiofluorination of diaryliodonium tosylates (XC₆H₄I⁺C₆H₄Y TsO⁻; 9.5 mM) in DMF-0.25% H₂O containing K 2.2.2-K₂CO₃ at 150 °C for 181 s.

XC6H4I+C6H4Y TsO−			Radioactivity recoverya (%)	RCY (%)b
#	X	Y		[18F]FC6H4X		[18F]FC6H4Y
1	H	H	96		49
2	H	2-Me	61	7		16
3	H	2-Br	87	0		14
4	4-OMe	2-CN	92	0		96
5	4-OMe	4-CO2Me	100	0		90
6	4-OMe	4-CN	100	0		83
7	4-OMe	2-Me	75	0		66
8	4-OMe	4-COC6H4-4′-Br	80	0		49
9	4-OMe	3-CO2Et	100	0		37
10	4-OMe	3-CF3	100	0		29
11	4-OMe	3-NO2	100	0		17
12	4-OMe	4-Ph	56	0		16
13	4-OMe	3-CN	73	4		11
14	4-OMe	4-F	97	0		13
15	4-OMe	4-OMe	92		12

^a% of infused radioactivity collected from the microfluidic apparatus at end of reaction.

^bRadiochemical yield measured by radio-HPLC as an average from two experiments.