Table 2. Multivariate analysis of various clinicopathologic factors in patients with gastric carcinoma.

Variable	Hazard ratio	95% confidence interval	P value
Tumor size [continuous variable]	1.042	1.022–1.062	< 0.0001
Age: Young (versus middle-aged)	1.577	1.079–2.304	0.019
Age: Elderly (versus middle-aged)	1.482	1.227–1.790	< 0.0001
Depth of invasion (T1–T4)*	2.066	1.812–2.356	< 0.0001
Lymph node metastasis (N0–N3)†	1.550	1.425–1.687	< 0.0001
Lymphatic vessel invasion (Ly0–Ly3)‡	1.207	1.108–1.314	< 0.0001
Blood vessel invasion (V0–V3)§	1.095	1.012–1.184	0.024
Peritoneal metastasis (presence or absence)	1.388	1.237–1.557	< 0.0001
Liver metastasis (presence or absence)	1.449	1.270–1.652	< 0.0001
Curability	2.532	1.972–3.257	< 0.0001

*T1, tumor invasion of the lamina propria or submucosa; T2, invasion of the muscularis propria or the subserosa; T3, penetration of the serosa; T4, invasion of adjacent organs.

†N0, no regional lymph node metastasis; N1–N3, metastasis in group-1 to -3 lymph nodes.

‡Ly0–Ly3, grade of lymphatic invasion.

§V0–V3, grade of blood vessel invasion.