Figure 1. Periosteal circumference measured in the pre-CC.

Periosteal circumference of the mid-diaphysis of the femur, as measured by peripheral quantitative computed tomography, is presented for 224 female (a) and 225 male (b) pre-CC mice.32 As these data are from mice still carrying a large degree of heterozygosity, values for individual mice are shown. The data for the progenitor strains are also presented and these strains are represented by red (a) and blue (b) bars, respectively. Note, that data were not available from female NZO/H1LtJ (a) and male NZO/H1LtJ and A/J inbred mice (a). Data are also presented as box and whisker plot to emphasize the greater variance in BMD in the CC mice as compared with the founder strains (c).