Table 2. Effects of bone seeking drugs on HSC and hematopoiesis.
| Drug | Effect on HSC and hematopoiesis | Effect on bone | Reference |
|---|---|---|---|
| Calcitonin | Inhibits egress of HSC from bone marrow | Inhibits bone resorption | 24 |
| Strontium ranelate | Delay hematopoietic recovery after HSC transplantation | Stimulates osteoblasts Inhibits osteoclasts | 6 |
| PGE2 | Expands hematopoiesis Increases HSC in bone marrow | Stimulates bone resorption | 29 |
| Erythropoietin | Expands erythropoiesis Induces oncostatin M release | Induces bone loss | 43,44,45,46 |
| PTH | Improves hematocrit Increments HSC in bone marrow Improve HSC engraftment after transplantation | Given intermittently stimulates osteoblasts Given continuously stimulates osteoclasts | 42,53 |
| Bisphosphonates | Reduce HSC in bone marrow Impair HSC engraftment after transplantation Abolish PTH-induced HSC increment in bone marrow Promote proliferation and subsequent differentiation of progenitors Increase HSC mobilization to circulation Decrease numbers of B cells in bone marrow | Induce osteoclast apoptosis Reduce bone resorption Block erythropoietin-induced bone loss | 48,49,50,51,52 |
| Anti-RANKL antibody |
Increases HSC mobilization to circulation |
Inhibits osteoclast formation |
50 |
Abbreviations: HSC, hematopoietic stem cell; PGE2, prostaglandin E2; PTH, parathyroid hormone.