Figure 1.

Short palate, lung, and nasal epithelial clone–1 (SPLUNC1) is produced by epithelial cells in the main airways. SPLUNC1 expression was assessed by immunostaining and Western blotting on lung sections and tissue homogenates from naive C57BL/6 mice. The trachea and proximal bronchi show that SPLUNC1 is abundantly expressed in the airway epithelium (A and B), whereas the expression of SPLUNC1 is decreased in the distal portion of the mainstem bronchi (B), and becomes undetectable in peripheral lung tissue (C).