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. 2013 Jun;48(6):717–724. doi: 10.1165/rcmb.2012-0072OC

Figure 5.

Figure 5.

Th1 and Th2 inflammation inhibit SPLUNC1. (A) SPLUNC1 was measured by ELISA in BALF from C57BL/6 (wild-type) mice with inflammation induced by Th1 or Th2 cells and inhaled ovalbumin (OVA). Mean values are shown (n = 5 mice/group), and are representative of three experiments. (B) SPLUNC1 was measured in BALF from CC10-rtTA-IL-13 doxycycline-inducible transgenic mice (Tg+) and littermate control mice (Tg−) treated with doxycycline (Dox) in drinking water for 14 days to induce allergic inflammation. Mice were 18 weeks of age, and higher SPLUNC1 concentrations were observed in Tg− mice, as expected. (C) SPLUNC1 was measured by ELISA in BALF from myd88+/+ and myd88−/− mice after the transfer of Th2 cells and inhaled OVA. Control mice did not receive a cell transfer or inhaled OVA. Mean values are shown (n = 5 mice/group), and are representative of three experiments. *P < 0.05.