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. 2013 Jun;48(6):765–772. doi: 10.1165/rcmb.2012-0362OC

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Copyright © 2013 by the American Thoracic Society

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Figure 4. — Targeted mutation of the Spag17 gene causes a central pair (CP) defect. (A) Transmission electron micrograph from a Spag17^+/+ mouse depicts a “9 + 2” microtubule arrangement. (B) Transmission electron micrograph from a Spag17^−/− mouse depicts axonemes lacking a microtubule in the CP (arrows). (C) High-magnification electron micrograph from a Spag17^+/+ mouse depicts a “9 + 2” microtubule arrangement. (D) High-magnification electron micrographs from a Spag17^−/− mouse depict axonemes lacking a microtubule in the central apparatus.