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Schematic representation of thiopurine methyltransferase (TPMT) alleles showing affected exons in stripe pattern, unaffected exons in dark gray, and untranslated parts of exons in white. The sizes of the exons are proportional to base pair length, whereas the introns are not. Nucleotide changes in the TPMT gene (given on the negative chromosomal strand, NCBI reference sequence NM_000367.2) are numbered such that the A in the ATG is + 1.
