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. Author manuscript; available in PMC: 2013 Jul 30.
Published in final edited form as: Sci Signal. 2012 May 8;5(223):pe11.

Fig. 1.

Fig. 1

Two orthogonal views of dimerized TLR receptors bound to ligand. (A) TLR2/1 forms a 2:1 receptor:ligand complex with lipopeptide. The recognition interface is centered on LRRs 9 to 12. (B) TLR3 recognizes dsRNA in a 2:1 complex using N- (LRR NT to LRR 3) and C-terminal (LRRs 19 to 21) segments. (C) TLR4 forms a 2:2:2 complex with MD-2 and LPS using LRR NT to LRR 5 and LRR 8 to 10. (D) TLR5 recognizes flagellin fragment FliC in a 2:2 complex using the first 10 LRR repeats (LRR NT to LRR 10). All TLRs share a common dimerization mode that involves the C-terminal LRR domains.

CREDIT: Y. HAMMOND/SCIENCE SIGNALING