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. 2013 Aug 1;24(15):2467–2476. doi: 10.1091/mbc.E13-04-0186

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© 2013 Ghiraldini et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 1: — Sirt1 is differently affected in hepatocytes of diabetic adults and normoglycemic old mice. (A) Sirt1 relative abundance in young-adult BALB/c mouse hepatocyte nuclei as determined by Western blotting. (B) Sirt1 relative activity in hepatocyte nuclei compared with young-adult BALB/c, determined by the Sirt1 Activity Assay Kit. Positive control, resveratrol (12.5 mM). (C) NAD⁺/NADH ratio in mouse hepatocytes. (D) Sirt1 representative image of the immunoblotting. Image was chosen to specifically highlight the differences shown in the graph. Histone H3 was used as loading control. B, BALB/c; N, NOD; +, hyperglycemia; –, normoglycemia. *Difference significant at p < 0.05 by ANOVA. ^†Difference significant at p < 0.05 by Student's t test.