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. 2013 Jul 27;10:26. doi: 10.1186/1476-9255-10-26

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Copyright © 2013 Smith et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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HA dose response of HAC gene expression. Dose response of unmodified HA (white markers) and the amide derivative of HA (black markers) on HAC expression of the indicated genes in the presence (solid line) and absence (dashed line) of IL-1β (2 ng/mL). Values are mean log fold-change from control (no IL-1 no HA; at zero) from six separate patients. Note different scales within each row. P < 0.05* different from no IL-1, no HA control; # different from IL-1, no HA control; ‡ different between the amide derivative and unmodified HA at the same concentration.