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Update of the craniofacial phenotype of the two sisters with oto-facial syndrome. (A, B) Elder sister at the age of 18 years with receding forehead, large nose and mouth, bilateral microtia with hypoplasia especially of the upper part of the ear with squared earlobe. (C, D) Younger sister at the age of 12 years with similar, but milder craniofacial dysmorphism.
