Figure 1. Motor abilities of the BAC LRRK2^R1441G Tg and NTg mice with age.

A. Number of rearing in the cylinder test. B. Latency to fall in the accelerated rotarod paradigm. C. Mean latency of staying gripped to the grid of a reverted cage lid. D. General activity in the open field test in a 15 min test: rearing (a), horizontal activity (b), activity in the center of the apparatus (c), and total number of fine activities (d). Data are means ± SEM, number of animals are indicated in the corresponding bar of the histogram. *p<0.05, **p<0.01, ***p<0.001 with MANOVA followed by post-hoc comparison (Bonferroni), and Student t test for single comparisons or Welch’s t test when variances were unequal.