Figure 3. Abnormal spermatogenesis in NOTCH1 gain-of-function mice.

A. Decrease in the testes weight in 50-, 140-, and 400-day-old mutant vs littermate control males. n≥3 in each group. *P<0.05. B. Age-dependent decrease in epididymal sperm counts in mutant males. The same animals as in A were used. *P<0.05. C. Normal spermatogenesis in control testes of different age (Stage 8) and corresponding sections from mutant animals. Note abnormal spermatogenesis (arrows) with no germ cells beyond spermatocyte stage and the distorted integrity of seminiferous tubules.