Table 3.
Substance | Platelet nadir | Bleeding | Confirmation |
---|---|---|---|
Cow’s milk | 5 × 109/L | Yes | Re-challenge |
Cranberry juice | 1 × 109/L | Yes | DDAbs |
Jui | 0 | Yes | Re-challenge |
Lupinus termis bean | 10 × 109/L | Not reported | Re-challenge |
Sesame seeds | 6 × 109/L | Yes | Re-challenge |
Walnut (Juglans regia) [46] | 4 × 109/L | Yes | Re-challenge and DDAbs |
Definite evidence = Ingestion of the substance preceded the thrombocytopenia and platelet count recovered once the substance was stopped; candidate substance was the only agent ingested or other agents were continued or re-introduced and platelet count remained normal; other etiologies of thrombocytopenia were excluded; confirmation in vivo with a re-challenge or in vitro with the demonstration of drug-dependent platelet antibodies (DDAbs).