TABLE II.

Hazard ratios for mortality associated with tumour size and other prognostic factors, by time since diagnosis

Variable	Period of analysis
	Diagnosis to 3 years						3 to 10 years
	Unadjusted			Adjusted			Unadjusted			Adjusted
	hr	95% ci	p Value	hr	95% ci	p Value	hr	95% ci	p Value	hr	95% ci	p Value
Age	0.97	0.95 to 1.00	0.05	0.98	0.95 to 1.01	0.11	0.97	0.95 to 0.99	0.004	0.97	0.95 to 0.99	0.007
Tumour size
1–19 mm	1.0			1.0			1.0			1.0
20 mm	1.73	1.15 to 2.69	0.008	1.51	1.01 to 2.27	0.05	1.18	0.84 to 1.65	0.33	1.04	0.74 to 1.45	0.82
21–29 mm	2.05	1.47 to 2.86	0.0001	1.59	1.14 to 2.23	0.006	1.89	1.47 to 2.43	0.0001	1.55	1.21 to 2.00	0.0006
Nodal status
Negative	1.0			1.0			1.0			1.0
Positive	3.53	2.55 to 4.89	0.0001	3.38	2.43 to 4.70	0.0001	3.48	2.71 to 4.46	0.0001	3.31	2.58 to 4.25	0.0001
er status
Negative	1.0			1.0			1.0			1.0
Positive	0.27	0.20 to 0.38	0.0001	0.28	0.20 to 0.40	0.0001	0.68	0.54 to 0.86		0.70	0.55 to 0.88	0.002

hr = hazard ratio; ci = confidence interval; er = estrogen receptor.