Table 2.
Characteristics of included studies in Type 2 diabetic adults
| Study | Country | Duration | n | Intervention | CGM Use | SMBG Use | Outcomes |
|---|---|---|---|---|---|---|---|
| Ehrhardt [34] |
USA |
3 months |
100 |
RT-CGM (DexCom SEVEN) vs. SMBG |
RT-CGM occurred in four cycles (2 weeks on/1 week off) for 3 months + SMBG before meals, at bedtime and at the time of hypo- or hyperglycemia |
SMBG before meals and at bedtime, at the time of hypo- or hyperglycemia |
• A1C |
| |
|
|
I:50 |
|
|
|
• Change in mean and distribution of blood glucose |
| |
|
|
C:50 |
|
|
|
|
| |
|
|
|
|
|
|
• Weight |
| |
|
|
|
|
|
|
• Blood Pressure |
| |
|
|
|
|
|
|
• Diabetes – related stress |
| Cosson [32] |
France |
3 months |
25 |
RT-CGM (The GlucoDay system) vs. SMBG |
48 hour of CGM at baseline and after 3 months + usual SMBG |
Usual SMBG |
• A1C |
| |
|
|
|
|
|
|
• Compare the 48 h CGM data at baseline with those obtained after 3 months: |
| |
|
|
I:11 |
|
|
|
|
| |
|
|
C:14 |
|
|
|
|
| |
|
|
|
|
|
- Glucose control |
|
| |
|
|
|
|
|
- Glucose variability |
|
| |
|
|
|
|
|
- Hypoglycemia |
|
| Allen [33] |
USA |
8 weeks |
46 |
RT-CGM vs. SMBG |
72 hour of CGM + SMBG |
SMBG |
• Physical activity self efficacy |
| |
|
|
I:21 |
|
|
|
|
| |
|
|
C:25 |
|
|
|
• Physical activity levels |
| |
|
|
|
|
|
• Blood pressure |
|
| |
|
|
|
|
|
• Body mass index |
|
| |
|
|
|
|
|
• A1C |
|
| Yoo [31] |
Korea |
3 months |
57 |
RT-CGM(Guardian RT) vs. SMBG |
Once a month for 3 day for 12 weeks + at least three SMBG per day |
SMBG at least four times a week, including fasting blood glucose and postprandial 2 h blood glucose levels for 3 months continuously |
• A1C |
| |
|
|
I: 29 |
|
|
|
• Fasting blood glucose |
| |
|
|
C:28 |
|
|
|
|
| |
|
|
|
|
|
|
• Post prandial 2 h blood glucose |
| |
|
|
|
|
|
|
• Lipid profiles |
| |
|
|
|
|
|
|
• Weight |
| |
|
|
|
|
|
|
• Waist circumference |
| • Body mass index |
Abbreviations: RT-CGM real-time CGM, SMBG self monitoring of blood glucose.