Figure 3. Influence of the subunit composition of PRC1 on the fate of hematopoietic stem cells.

The subunit composition of the polycomb repressive complex (PRC1) is responsible for the balance between self-renewal and differentiation of hematopoietic stem cells. Cbx7 and Cbx8 compete for integration into the PRC1 complex. While Cbx7 inhibits HSC differentiation and induces self-renewal, Cbx8 has the opposite effect. Interaction types indicate ‘is part of’ (red arrow), ‘increase activity’ (green arrow), ‘affects activity’ (open green arrow), ‘increase expression’ (black arrow) and ‘interacts’ (red line). T-bar arrows indicate inhibitory behaviour.