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. 2013 Jul 30;8(7):e70348. doi: 10.1371/journal.pone.0070348

Table 3. Bone marrow stromal cell types (vascular/endothelial) known to contribute to the hematopoietic microenvironment.

PMID Author Niche cell type Niche factor HSC counterpart HSC sub-type Signaling process Role
Vascular niche 19797522 Lewandowski et al., 2010 Vascular endothelial cell (Pecam1+) Vascular cell adhesion molecule 1 (Vcam1) CFSE-labeled CD34-KSL
15989959 Kiel et al., 2005 Sinusoidal endothelium (MECA-32+) CD150+CD48-CD41-Lin-
17174120 Sugiyama et al., 2006 CAR cells (Cxcl12+) C-X-C motif ligand 12 (Cxcl12) C-X-C chemokine receptor type 4 (Cxcr4) Sca1+cKit+/CD150+CD48-CD41- CXCL12/CXCR4 signaling HSC quiescence
20207228 Butler et al., 2010 Sinusoidal endothelium (VE-cadherin+) Jagged Notch TNR.GFP+ Notch signaling pathway
22118468 Yamazaki et al., 2011 Sinusoidal endothelium (VE-cadherin+) CD150+CD48-CD41-Lin-
22281595 Ding et al., 2012 Sinusoidal endothelium Stem cell factor (SCF,Kitl) Kit oncogene (c-Kit) CD150+CD48-Lin- HSC maintenance
22118468 Yamazaki et al., 2011 Non-myelinated Schwann cell (GFAP+) Integrin beta 8 (Itgb8) Tgf-beta receptor CD150+CD48-CD41-Lin- Tgf-beta/SMAD signaling HSC quiescence
20703299 Méndez-Ferrer et al., 2010 MSC (Nestin+) CD150+CD48-Lin- HSC homing
22281595 Ding et al., 2012 Perivascular cell (Lepr+) Stem cell factor (SCF,Kitl) Kit oncogene (c-Kit) CD150+CD48-Lin- HSC maintenance
22983360 Ludin et al., 2011 Monocytes-macrophage (alpha-SMA+) Prostaglandin-endoperoxide synthase 2 (Ptgs2, Cox2), C-X-C motif ligand 12 (Cxcl12) C-X-C chemokine receptor type 4 (Cxcr4) CD150+CD48-CD41- ROS signaling/CXCL12/CXCR4 signaling HSC maintenance
21282381 Chow et al., 2011 Macrophage (CD169+)+MSC (Nes+) C-X-C motif ligand 12 (Cxcl12) C-X-C chemokine receptor type 4 (Cxcr4) CD135-KSL CXCL12/CXCR4 signaling HSC adhesion/mobilization
21115812 de Graaf et al., 2010 Megakaryocyte Thyroid peroxidase (Tpo) Myeloproliferative leukemia virus oncogene (Mpl) CD34-CD135-KSL TPO/MPL signaling