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. 2013 Jul 30;8(7):e70496. doi: 10.1371/journal.pone.0070496

Figure 3. High expression of Hsp90 and its compromised secretion by peripheral blood mononuclear cells of bullous pemphigoid patients.

Figure 3

Hsp90 was detected in whole cell lysates of freshly isolated peripheral blood mononuclear cells (PBMCs) as well as in conditioned medium of PBMC cultures of bullous pemphigoid (BP) patients and healthy controls by enzyme-linked immunosorbent assay. (a) The mean intracellular Hsp90 content of PBMCs was comparatively higher in BP patients. (b) The mean extracellular Hsp90 content of PBMC cultures was comparatively lower in BP patients after 18-hour stimulation with LPS/CpG and TNF-α. Values are mean ± SEM of 5 BP patients and 5 controls. *P<0.05.