Table 3. Pathological characteristics of H.pylori-positive and negative chronic cholecystitis.
| Characteristics | No. of Patients n(%) | ||
| H.pylori (+) in gallbladder mucosa (n = 67) | H.pylori (−) in gallbladder mucosan(n = 259) | p value | |
| Postoperative and Pathological Diagnosis | |||
| Gallstone | |||
| Cholesterol Stones | 14(25.45) | 68(32.08) | NS |
| Pigment Stones | 8(14.55) | 35(16.51) | NS |
| Mixed Stones | 33(60.00) | 109(51.42) | NS |
| Polypoid Lesion | |||
| Cholesterol Polyp: Inflammatory Polyp | 10∶2 | 45∶2 | NS |
| Gallbladder Adenomyomatosis | 35(52.24) | 92(35.52) | 0.012▴ |
| Xanthogranulomatous Cholecystitis | 5(7.46) | 12(4.63) | NS |
| Histological Analysis of Cholecystitis | |||
| Inflammatory mononuclear infiltrate | NS | ||
| Mild | 31(46.27) | 131(50.58) | |
| Moderate | 22(32.84) | 89(34.36) | |
| Severe | 14(20.90) | 39(15.06) | |
| Degree of Fibrosis | NS | ||
| Mild | 45(67.16) | 188(72.59) | |
| Moderate | 14(20.90) | 54(20.85) | |
| Severe | 8(11.94) | 17(6.56) | |
| Thickness of Muscular Layer | NS | ||
| Mild | 30(44.78) | 120(46.33) | |
| Moderate | 22(32.84) | 103(39.77) | |
| Severe | 15(22.39) | 36(13.90) | |
| Adipose Tissue Deposition | NS | ||
| Mild | 33(49.25) | 166(64.09) | |
| Moderate | 27(40.30) | 73(28.19) | |
| Severe | 7(10.45) | 20(7.72) | |
| Degree of Hyperplasia | NS | ||
| Diffuse | 25(37.31) | 115(44.40) | |
| Focal | 42(62.69) | 144(55.60) | |
| Dysplasia | NS | ||
| Low-grade | 3(4.48) | 8(3.09) | |
| High-grade | 0(0.00) | 0(0.00) | |
| Metaplasia | 9(13.43) | 14(5.41) | 0.022▴ |
| Immunoreactive score of iNOS | 6.06±1.59 | 5.12±1.34 | 0.012▴ |
| Immunoreactive score of ROS | 5.01±2.01 | 3.99±1.87 | 0.000* |
*
p<0.01,
▴
p<0.05.
NS: not significant.
N/A: not applicable.