Table 1. Clinical characteristics of patients that passed gene expression and genotyping quality control filters.
| Laval (n = 409) | UBC (n = 339) | Groningen (n = 363) | |
| Male (%) | 55.9 | 53.7 | 53.2 |
| Age (years) | 63.3±9.9 | 60.2±14.3 | 51.5±15.5 [9] |
| Body Mass Index (kg/m2) | 26.7±5.3 | 25.6±5.4 [56] | 23.2±4.2 [42] |
| FEV1 predicted - pre-BD* (%) | 80.5±18.9 [16] | 78.2±24.4 [77] | 60.5±30.0 [194] |
| FVC predicted – pre-BD* (%) | 89.8±16.1 [31] | 86.9±20.1 [75] | 75.0±26.5 [208] |
| FEV1/FVC | 0.67±0.10 [32] | 0.67±0.13 [77] | 0.64±0.19 [189] |
| COPD | 211 (51.6%) [34] | 115 (33.9%) [99] | 158 (43.5%) [120] |
| Stage 1 : Mild | 82 (38.9%) | 43 (37.4%) | 20 (12.6%) |
| Stage 2 : Moderate | 117 (55.4%) | 60 (52.2%) | 38 (23.9%) |
| Stage 3 : Severe | 11 (5.2%) | 2 (1.7%) | 21 (13.2%) |
| Stage 4 : Very Severe | 1 (0.5%) | 10 (8.7%) | 69 (43.4%) |
| Asthma | 15 (3.7%) | 22 (6.5%) | 0 (0.0%) |
| Diabetes | 41 (10.0%) | 13 (3.8%) | 27 (7.4%) |
| Cardiac diseases | 120 (29.3%) | 46 (13.6%) | 28 (7.7%) |
| Smoking | |||
| Smoker | 90 (22.0%) | 98 (28.9%) | 57 (15.7%) |
| Ex-Smoker | 283 (69.2%) | 163 (48.1%) | 185 (51.0%) |
| Non-Smoker | 36 (8.8%) | 26 (7.7%) | 100 (27.5%) |
| Not available | 0 (0.0%) | 52 (15.3%) | 21 (5.8%) |
| Pack-years in ever-smokers | 48.5±27.5 [37] | 44.7±28.5 [58] | 31.2±17.4 [51] |
FEV1 : forced expiratory volume in 1 second.
FVC : forced vital capacity.
[-] = missing value.
*
pre-BD: pre-bronchodilator.