Table 1.

Baseline characteristics of Age-Related Eye Disease Study (AREDS) participants included in analyses

	Analysis
	Mortality Analysisψ		Treatment Analysis of Categories 2, 3, 4		Treatment Analysis of Categories 3, 4		Treatment Analysis of Category 4
	N	%	N	%	N	%	N	%
	Total	4753	100.0	3476	100.0	2459	100.0	901	100.0
Age-Related Macular Degeneration (AMD) category
1	1116	23.5	0	0	0	0	0	0
2	1060	22.3	1017	29.3	0	0	0	0
3	1620	34.1	1558	44.8	1558	63.4	0	0
4	957	20.1	901	25.9	901	36.6	901	100.0
AREDS treatment
Placebo	1483	31.2	861	24.8	598	24.3	215	23.9
Antioxidants	1480	31.1	891	25.6	636	25.9	239	26.5
Zinc	903	19.0	865	24.9	607	24.7	223	24.8
Antioxidants + Zinc	887	18.7	859	24.7	618	25.1	224	24.9
Age
<65	1000	21.0	654	18.8	415	16.9	135	15.0
65-69	1577	33.2	1109	31.9	720	29.3	213	23.6
≥70	2176	45.8	1713	49.3	1324	53.8	553	61.4
Sex
Female	2655	55.9	1964	56.5	1353	55.0	470	52.2
Male	2098	44.1	1512	43.5	1106	45.0	431	47.8
Educationa
High school or less	1705	35.9	1298	37.4	973	39.6	420	46.6
Some college	1409	29.7	1042	30.0	743	30.2	265	29.4
College graduate	1636	34.4	1134	32.6	741	30.2	216	24.0
Race
Non-White	207	4.4	121	3.5	65	2.6	14	1.6
White	4546	95.6	3355	96.5	2394	97.4	887	98.4
Smoking status
Never	2105	44.3	1507	43.4	1003	40.8	316	35.1
Former	2273	47.8	1686	48.5	1225	49.8	464	51.5
Current	375	7.9	283	8.1	231	9.4	121	13.4
Body Mass Index (BMI)a
<24.9	1550	32.6	1122	32.3	772	31.4	250	27.7
25-29.9	1984	41.8	1458	42.0	1029	41.9	368	40.8
≥30	1216	25.6	895	25.8	657	26.7	283	31.4
Hypertension
Normal	2869	60.4	2076	59.7	1419	57.7	479	53.2
Controlled	1177	24.8	877	25.2	653	26.6	264	29.3
Uncontrolled and treated	346	7.3	252	7.2	187	7.6	76	8.4
Uncontrolled and untreated	361	7.6	271	7.8	200	8.1	82	9.1
Angina
No	4264	89.7	3114	89.6	2168	88.2	774	85.9
Yes	489	10.3	362	10.4	291	11.8	127	14.1
Diabetes
No	4357	91.7	3190	91.8	2249	91.5	814	90.3
Yes	396	8.3	286	8.2	210	8.5	87	9.7

^a3 with missing education, and 2 with missing BMI data

^ψThis study cohort includes AMD Category 1, 2, 3, and 4 participants