Figure 2. Peripheral nerve injury-induced mechanical allodynia in WT/TRPM2-KO BM chimeric mice.

In the pSNL model of neuropathic pain, the 50% withdrawal threshold to mechanical stimuli was determined in the ipsilateral (A) and contralateral paws (B) of TRPM2^BM+/Rec+, TRPM2^BM–/Rec+, TRPM2^BM+/Rec–, and TRPM2^BM+/Rec+ mice. *p < 0.05; **p < 0.01; ***p < 0.001, compared with TRPM2^BM+/Rec+ mice. ^# p <0.05; ^## p <0.01, compared with Day 0 in each BM chimeric mouse group. n = 5–7. Data are expressed as the mean ± SEM.